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processing of human lymphoid aggregates

Mechanisms of human lymphoid chromosomal

2016.5.25  Biochemical analyses on the mechanisms of DNA breakage and rejoining permit formulation of detailed models of the human chromosomal translocation process in lymphoid neoplasms.

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Measurement of lymphocyte aggregation by flow

2015.6.17  Aggregation of lymphocytes is often an outcome of the activation of various signaling pathways, and is associated with fundamental cellular responses

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Processing human lymph node samples for single-cell assays

2021.12.12  Here, we describe a time-efficient but gentle protocol to process human lymph node samples. This protocol avoids enzymatic or mechanical stress and was

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Identification, isolation and analysis of human gut

2021.2.22  Nature Protocols - The authors present a protocol for isolating and studying human gut-associated lymphoid tissue.

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Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that

They observed that afferent lymph, with its typical low protein content, is filtered in the LN so that water is absorbed into the venous vasculature and efferent lymph emerges

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GI biopsies with lymphoid aggregates: What does this

2020.10.15  Lymphoid aggregate/infiltrate: A collection of B cells, T cells, and supporting cells, present within the stroma of various organs. The term can be used to

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Organogenesis of lymphoid tissues Nature Reviews

2003.4.1  Drawing on studies of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model of lymphoid-tissue development, involving

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Lymphoid aggregates in gastric biopsies: relationship to other

PMID: 10912626. The purpose of this study is to estimate the prevalence of lymphocyte aggregates (precursor of MALT lymphomas) in gastric mucosal biopsies and to

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Single-cell analysis reveals the continuum of human

2017.11.21  Nature Immunology - Vyas and colleagues show that a continuum of hemopoietic progenitor cells from human cord blood execute lymphoid and myeloid

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Processing the lymph node biopsy - PubMed

Processing the lymph node biopsy. 2014;1180:271-82. doi: 10.1007/978-1-4939-1050-2_15. Department of Pathology, USC Keck School of Medicine, Los Angeles, CA, USA.

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Lymphoid aggregate MyPathologyReport.ca

2022.3.24  A reactive lymphoid aggregate is a group of non-cancerous lymphoid cells (immune cells) that are reacting or responding to conditions and signals in their environment. These signals and conditions

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Identification, isolation and analysis of human gut

2021.2.22  The authors present a protocol for isolating and studying human gut-associated lymphoid ... The sample processing time of this method is long ... M. L. Basal lymphoid aggregates in ...

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Lymphoid Aggregates in Endobronchial Biopsies from Young

1997.11.4  Processing of Bronchial Biopsies. ... Previous observations of lymphoid aggregates in human airways were made in studies of lung tissue obtained either at surgery or at post mortem. The aggregates in our study have similarities as well as differences to BALT as described in animal and human lung tissue (1, 2, 11, 12).

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Tertiary lymphoid structures in cancer – considerations for patient ...

2020.5.15  Studies observing TLS, lymphoid aggregates, or SLOs, ... A. et al. Human NKp44+ group 3 innate lymphoid cells associate with tumor-associated tertiary lymphoid structures in colorectal cancer.

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Tertiary Lymphoid Structures in the Central Nervous System ...

2021.9.1  TLS are ectopic aggregates of lymphoid and stromal cells that are transiently formed in non-lymphoid ... The TLS in human gliomas formed around ... Morbini P, Benericetti E, Ceroni M, et al. Human Leukocyte Antigen and Antigen Processing Machinery Component Defects in Astrocytic Tumors. Clin Cancer Res (2005)

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Stromal Cells Covering Omental Fat-Associated Lymphoid

2020.4.14  For decades, the omentum has been known as the policeman of the abdomen. Jackson-Jones et al. reveal the existence of specialized mesothelial cells within fat-associated lymphoid clusters of the omentum that are responsible for the capture of peritoneal contaminants via the formation of neutrophil aggregates, preventing systemic

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Co-localization of lymphoid aggregates and lymphatic networks

2018.1.25  In the human head, most of the lymphoid tissue is organized as tonsils in Waldeyer’s ring, whereas rodents do not have tonsils. ... Moreover, it was described that lymphoid aggregates forming in the bowel of Crohn’s disease patients are in close contact to efferent and afferent lymph vessels of nearby lymph nodes, ...

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Characterization of bone marrow CD4 to CD8 ratios and ... - Springer

2021.10.9  Lymphoid aggregates were encountered in 50% of living patients and 31% of autopsy bone marrows. As none of the patients had a history of hematolymphoid disease, and most of the aggregates were found in older decedents, these are likely non-neoplastic or so called “physiologic” aggregates [ 9 , 11 ].

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Innate lymphoid cells: major players in inflammatory diseases

2017.8.14  Innate lymphoid cells (ILCs) have attracted much attention from the immunology community in recent years. This Review discusses the contribution of ILCs to different inflammatory diseases and the ...

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Frontiers Lymphoid Aggregates in the CNS of Progressive

2020.1.15  In gray matter pathology of multiple sclerosis, neurodegeneration associates with a high degree of meningeal inflammatory activity. Importantly, ectopic lymphoid follicles (eLFs) were identified at the inflamed meninges of patients with progressive multiple sclerosis. Besides T lymphocytes, they comprise B cells and might

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Lymphoid aggregates in Crohn's colitis and mucosal immunity

2013.8.25  a Crohn's colitis showing the paucity of activated T cells, committed B cells, and plasma cells in a mucosal lymphoid aggregate. In contrast, a high number of aT/cB/PC in the lamina propria surrounding colonic crypts are seen on top (Crohn's colitis, MUM1 immunostain, ×20). b Normal colonic mucosa showing a high number of

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Tertiary lymphoid structures (TLS) identification and density

2021.9.23  Tertiary lymphoid structures (TLS) are ectopic aggregates of lymphoid cells in inflamed, infected, or tumoral tissues that are easily recognized on an HE histology slide as discrete entities, distinct from lymphocytes. TLS are associated with improved cancer prognosis but there is no standardis

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CD8 + T cells in human uterine endometrial lymphoid aggregates ...

Lymphoid aggregates (LA) develop during the proliferative phase of the menstrual cycle in the human uterine endometrium (EM). They contain mostly CD8 + T cells and B cells. As these LA are absent immediately following menses, they may arise by division of cells resident in the EM, or by division of a limited number of precursor cells that traffic into the

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Tertiary lymphoid structure score: a promising approach to refine

2021.3.15  The lymphoid aggregates ... Wang, X., Van Den Eyden, G. et al. Reliability of tumor-infiltrating lymphocyte and tertiary lymphoid structure assessment in human ... (tissue processing ...

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Frontiers Mechanisms of tertiary lymphoid structure formation ...

2023.9.4  TLS are B and T cell lymphoid aggregates observed histologically in chronically inflamed peripheral tissues such as those found in solid tumors, persistent infections, ... , a function previously shown to shape CD4 + T cell responses in human tumors . Regardless of exactly how TLS support anti-tumor immunity, ...

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B cells and tertiary lymphoid structures promote immunotherapy

2020.1.15  Structures were identified as aggregates of lymphocytes having histological features with analogous structures to that of lymphoid tissue with germinal centres (including B cells (CD19/20), T ...

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Tertiary Lymphoid Structures in Cancers: Prognostic Value,

2016.10.3  In human breast cancer, Tregs were detected in lymphoid aggregates surrounding tumor nests, and their presence was linked with the poor clinical outcome of patients . In mice bearing breast tumors, Treg depletion led to an increased density of HEV within the tumor, facilitated T cell recruitment from the blood, and ultimately induced

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Lymphoid and Hematopoietic Systems (Lymph Nodes, Thymus

2023.1.1  The cortex contains scattered follicles (Fig. 7.1b) that are predominantly populated by mature B cells.In quiescence, the lymphoid follicles appear as nodular aggregates of small mature lymphocytes with condensed chromatin and are termed primary follicles [].During an immune response, the follicles develop germinal center reactions

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Frontiers A Detailed Analysis of Parameters Supporting the ...

2021.3.9  By Phase 4, CLL B cells are for the most part lost with only T cells remaining. The required B-T cell interactions are not dependent on other human hematopoietic cells nor on murine macrophages or follicular dendritic cells, which appear to be relatively excluded from the perivascular lymphoid aggregates. Notably, the growth

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Differentiating Benign From Malignant Bone Marrow B-Cell Lymphoid

2015.2.1  The presence of lymphoid aggregates in the bone marrow has been reported to be more frequently associated with certain conditions including aging, autoimmune diseases, inflammatory conditions, and infectious disorders. 2,9 They have also been reported to be commonly identified in patients with myeloproliferative neoplasms,

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